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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E
All Species:
30
Human Site:
T210
Identified Species:
41.25
UniProt:
P06730
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06730
NP_001959.1
217
25097
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Chimpanzee
Pan troglodytes
XP_523824
217
24938
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Rhesus Macaque
Macaca mulatta
XP_001092045
253
28850
L246
T
A
T
K
S
N
S
L
A
K
N
K
F
V
V
Dog
Lupus familis
XP_544992
217
25075
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTA9
244
27967
Rat
Rattus norvegicus
P63074
217
25035
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514651
236
27161
E225
K
I
A
I
W
T
T
E
C
E
N
R
D
A
V
Chicken
Gallus gallus
XP_420655
217
25026
T210
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Frog
Xenopus laevis
P48597
213
24616
T206
T
A
T
K
S
G
S
T
T
K
N
R
F
V
V
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
T208
T
A
T
K
S
G
S
T
T
K
N
K
F
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
N252
T
M
V
K
Q
G
S
N
V
K
S
I
Y
T
L
Honey Bee
Apis mellifera
XP_624290
213
24784
Q206
V
M
V
K
V
G
S
Q
T
K
N
A
Y
V
V
Nematode Worm
Caenorhab. elegans
O61955
248
27791
T205
S
S
A
R
T
S
S
T
V
K
P
R
I
C
L
Sea Urchin
Strong. purpuratus
NP_001091928
225
25645
M218
T
M
T
K
T
G
S
M
A
K
S
L
Y
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23252
235
26501
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
H206
H
S
S
A
N
G
R
H
P
Q
P
S
I
T
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
59.2
99.5
N.A.
53.2
98.1
N.A.
71.6
92.1
88.4
82.9
N.A.
43.6
54.8
41.1
53.7
Protein Similarity:
100
98.6
69.1
99.5
N.A.
69.2
98.6
N.A.
74.1
94
94
92.6
N.A.
56.3
68.6
58.8
73.7
P-Site Identity:
100
100
73.3
100
N.A.
0
100
N.A.
20
100
100
93.3
N.A.
33.3
53.3
26.6
46.6
P-Site Similarity:
100
100
80
100
N.A.
0
100
N.A.
33.3
100
100
100
N.A.
53.3
60
60
66.6
Percent
Protein Identity:
N.A.
42.2
N.A.
39.5
31.8
N.A.
Protein Similarity:
N.A.
56.8
N.A.
54
55.3
N.A.
P-Site Identity:
N.A.
0
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
48
12
6
0
0
0
0
12
0
0
6
0
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
6
0
0
0
0
6
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% D
% Glu:
0
0
0
0
0
0
0
6
0
6
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
48
0
0
% F
% Gly:
0
0
0
0
0
65
0
0
0
0
0
0
0
0
0
% G
% His:
6
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% H
% Ile:
0
6
0
6
0
0
0
0
0
0
0
6
12
0
0
% I
% Lys:
6
0
0
65
0
0
0
0
0
71
0
12
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
6
0
0
0
6
0
0
18
% L
% Met:
0
18
0
0
0
0
0
6
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
6
6
0
6
0
0
59
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
6
0
12
0
0
0
0
% P
% Gln:
0
0
0
0
6
0
0
6
0
6
0
0
0
0
0
% Q
% Arg:
0
0
0
6
0
0
6
0
0
0
0
48
0
0
0
% R
% Ser:
6
12
6
0
48
6
71
0
0
0
12
6
0
0
0
% S
% Thr:
59
0
53
0
12
6
6
48
48
0
0
0
0
18
0
% T
% Val:
6
0
12
0
6
0
0
0
12
0
0
0
0
53
65
% V
% Trp:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
18
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _